Item

Urinary protein concentrations in PRIORITY prior to randomization

Title
Urinary protein concentrations in PRIORITY prior to randomization
Description
Urinary protein concentrations in PRIORITY prior to randomization.

The Early Detection of Diabetic Kidney Disease by Urinary Proteomics and Subsequent Intervention with Spironolactone to Delay Progression (PRIORITY) study was a multicentre, prospective, observational study with embedded randomised controlled trial, which recruited people with type 2 diabetes, normal urinary albumin excretion, and preserved renal function. All participants (observational cohort) were tested with the CKD273 classifier and classified as high risk (CKD273 classifier score >0·154) or low risk (≤0·154). Participants, who were classified as high risk were entered into a randomised controlled trial and randomly assigned (1:1) by use of an interactive web-response system, to receive spironolactone 25 mg once daily or matched placebo (trial cohort).
The DC-ren project selected 79 patients from this cohort for in-depth molecular characterization for baseline measurements of blood and urinary biomarker candidates. The here described data set comprises urinary marker concentrations measured by Mesoscale as well as selected clinical routine lab measurements determined in whole blood. Data from a total 79 study visits are available.
Subject
Medicine, Health and Life Sciences
Creator
DC-ren Project
Contributor
Contact: SILVESTRI, Claudio
Publisher
Ca' Foscari University of Venice — Datarepository Unive
Date
2025
Identifier
DOI: https://doi.org/10.71731/DATA_UNIVE/8PFPDE
Type
Dataset
Source
https://doi.org/10.71731/DATA_UNIVE/8PFPDE
Relation
0 file(s) in dataset
Rights
All samples and data were obtained from individuals who gave written informed consent specifically permitting their use for the clinical study's stated objectives. Anyone seeking access to measurements (Data) obtained from the clinical study samples must seek a data access agreement. In a first step the Project, in which the Data will be used must be described and individuals who will have access to the data must be identified. You must agree to only use the Data for the purpose of the Project. Depending on type and area of research, additional institutional review board approval may be necessary.
Educational Level
Higher education | research
Interactivity Type
Active
Item sets
Ca' Foscari University of Venice